Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate is a thiazole heterocyclic compound and an important pharmaceutical intermediate, mainly used in the synthesis of febuxostat. It appears as a white crystalline powder with high purity and good stability. It is insoluble in water but soluble in most organic solvents, has no special volatility, and is classified as an ordinary non-hazardous chemical.
Physical & Chemical Properties
Molecular FormulaC13H13NO3S
Density:1.27g/cm³g/cm³
Boiling Point:
Solubility:
Insoluble in water; freely soluble in methanol, ethanol, dichloromethane, DMSO and DMF; slightly soluble in ethyl acetate and acetone; insoluble in n-hexane and petroleum ether.
Molecular Weight:263.31g/mol
Flash Point:211.9±31.8℃
Melting Point:180℃
Uses
1. Core Uses:Key intermediate (Intermediate 2) for febuxostat, a drug for gout.
2. Used in the synthesis of APIs for the treatment of hyperuricemia and gout.
3. Serves as an organic synthesis scaffold for thiazole derivatives, used in the preparation of biologically active heterocyclic compounds.